Wednesday, April 25, 2018

Study reveals the inner workings of a molecular motor that packs and unpacks DNA

Precision, complexity, organization, heavy duty, astounding , react rapidly to alterations in their environment - all through BUC.

The more we learn the harder it is for evo proponents to advocate with a straight face. It looks designed but we know it isn’t. :grinning:

Study reveals the inner workings of a molecular motor that packs and unpacks DNA
Moreover, the entire DNA must be replicated before cell division and DNA damage needs to be repaired.

This is when chromatin remodelers come into play. Chromatin remodelers have an essential role as they are molecular machines: they unpick and unpack segments of the DNA by sliding nucleosome spools back and forth, replacing individual histones, freeing up the DNA for transcription, and finally compacting it again, when the job is done. Since all of this happens in a highly dynamic fashion, chromatin remodelers enable cells to react rapidly to alterations in their environment – and this holds for brewer’s yeast as well as for human cells. In mediating gene accessibility, chromatin remodelers are vital for development and cell differentiation; cell types are defined by the sets of genes they express, remodelers help to determine cell identity.

From a biochemical point of view, remodelers are responsible for heavy-duty reorganizational tasks. To perform these tasks, they must execute “large-scale conformational changes, which are carried out with astounding precision,”

The clouds of spaghetti that keep DNA data safe

The clouds of spaghetti that keep DNA data safe

Cells can avoid “data breaches” when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert Einstein College of Medicine have shown. Their study appears in the March 23 issue of the Journal of Biological Chemistry.

In every human cell, all of the body’s blueprints and instructions are stored in the form of DNA inside the nucleus. Molecules that need to travel in and out of the nucleus – to turn genes on or off or retrieve information – do so through passageways called nuclear pore complexes (NPCs). Traffic through these NPCs must be tightly controlled in order to prevent DNA hijacking by viruses or faulty functioning as in cancer.

"How on Earth do you have the kind of specificity that we see in protein-protein interactions like antibodies, and yet have the kind of speed that we see with water off a Teflon pan?"

"I can’t think of any analogy in normal life that does what this does," Rout said. "You’ve got this blur of (amino acids) coming on and off (the transport factor) with extraordinary speed."

Sunday, December 24, 2017

Royal Society Meeting - Modern Synthesis is Broken

Read a report on the Royal Society Meeting
“The Modern Synthesis, while undoubtedly productive for a time, is a misconception of reality that has reached the limits of its explanatory power. The problems are fundamental. No amount of cosmetic surgery is going correct them.”
“To the contrary, Darwinian competition causes not the evolution of species but the destruction of species.It is collaboration in its various forms that causes biological evolution. Hence I’m surprised by calls for extending the neo-Darwinian Evolutionary Synthesis. You can’t extend something that is broken. Surely what is needed now, after 65 years, is using the empirical evidence to develop a new paradigm for biological evolution.”
"If you want the definition of the Modern Synthesis, take a look at how Neil deGrasse Tyson explains evolution in the 2014 remake of Carl Sagan’s Cosmos series. Tyson, an astrophysicist, is unaware that he is misinformed, as are most in science, academia, government, literature, the arts, and the public by this outmoded theory of evolution."
“Shuker tried to interrupt but Noble held his ground:
‘No, YOU need to listen. I used to think exactly like you. I embraced the reductionist mindset for years. When I got out of school I was a card-carrying reductionist. Reductionism is powerful and it’s useful. I am not dissing it. Many times we need it. But it is not the whole story.’ Noble described how bacterial regulatory
networks rebuilt those genes in four days by hyper-mutating, actively searching for a solution that would give them tails and enable them to Nind food. Natural selection did not achieve that. Natural genetic engineering did.’”
“It’s appropriate that this meeting is being held at the Royal Society, whose motto, we were reminded yesterday, is “Nullius in verba”: Accept nothing on authority."
“Not one whit of empirical evidence shows that new species arise from the neo-Darwinian mechanism. To the contrary, Darwinian competition causes not the evolution of species but the destruction of species.”

Monday, April 3, 2017

ATP Synthase: The power plant of the cell

ATP Synthase: The power plant of the cell - has a rotor, stator, driveshaft and camshaft.  The amazing design of life on display in this animation.  Another chicken and egg question:  What came first the motor or the energy?

Thursday, March 23, 2017

Sophistication, coordination and communication of cells

Each day we learn more that supports the complexity of life.  Cells communicating, cooperating, working in concert, aware of each other all by chance.  Not a chance.  It smacks of design and programming. 

How cells communicate to move together as a group

Two cell membrane proteins, Fat2 and Lar, trigger leading and trailing edge movements during epithelial migration

A new signaling system has been discovered that epithelial cells use to coordinate their individual movements and efficiently move tissues, report scientists.  

"When an individual cell needs to move somewhere, it manages just fine on its own. It extends protrusions from its leading edge and retracts the trailing edge to scoot itself along, without having to worry about what the other cells around it are doing. But when cells are joined together in a sheet of tissue, or epithelium, they have to coordinate their movements with their neighbors. It's like walking by yourself versus navigating a crowded room. To push through the crowd, you have to communicate with others by talking ("Pardon me") or tapping them on the shoulder. Cells do the same thing, but instead of verbal cues and hand gestures, they use proteins to signal to each other."

Sunday, February 12, 2017

In The Beginning...Are religion and science at war?

Scientism (see the Magician's Twin)has caused many people to lose their faith.  Faith and reason cannot be opposed as they flow from the same truth, aka God.  Are Christianity and science at war with each other?  Are we now in the real "Dark Ages"?  Salvo takes this on:

In the Beginning

Episodes in the Origin & Development of Science

"Not according to leading historians. "The greatest myth in the history of science and religion holds that they have been in a state of constant conflict," wrote historian of science Ronald Numbers in 2009.1 Even though he and other historians of science have documented this conclusion thoroughly, many myths about the alleged warfare between science and theistic religion continue to be promulgated in popular literature and textbooks."

"This distinction is especially helpful when encountering statements from scientists that purport to be scientific but, on closer examination, prove actually to be theological, and thus outside the domain of science. Take the following statement by Stephen Hawking, for example, which appeared in his bestselling, co-authored book The Grand Design: "Because there is a law like gravity, the universe can and will create itself from nothing."2

Sunday, January 22, 2017

Monday, December 5, 2016

Is Earth Fine Tuned for Fire?

The following video adds to the list of fine tuned parameters for life.   Every time another is added it strengthens the case for design.  Man has the ideal body to make a fire.

Monday, July 18, 2016

New Book - Undeniable - Doug Axe

A remarkable thing about evolutionary theory is the way it demands that we deny our intuition at almost every step. Evolutionists then assure us that the science is all figured out, so we needn't trouble our silly heads about the relevant biology. In his new book, Douglas Axe of Biologic Institute turns this standard assurance on its head. In Undeniable: How Biology Confirms Our Intuition That Life Is Designed (HarperOne 2016), Dr. Axe restores the place of intuition alongside intellect in considering the question of life's origins.

Friday, May 6, 2016

Just how difficult is the Origin of Life problem?

In this video James Tours describes his work with nanocars and the difficulty of solving the Origin of Life problem. 

Time is enemy as products of reactions degrade
Dream team could not develop a cell
Nobody understands
When will science community confess they have no clue
Abiogenesis nightmare

"Some may contend that I did not use Nature’s building blocks, such as carbohydrates, amino acids, nucleic acids and lipids. I concede, I took the easy route and used simple synthetic molecules, not Nature’s far more complex compounds where chirality and diastereoselectivity can be enormously problematic in synthesis. Thus here we will consider Nature’s building blocks, showing that many of the common parameters hold, yet they become far more difficult for prebiotic systems than for the synthetic chemist today."

Sunday, April 10, 2016

Humans may have lost abilities that our ancestors had

If our ancestors had the ability to regenerate teeth and limbs and now we can't; would this be evolution?   Or is it devolution?

From ScienceDaily:

Genetic elements that drive regeneration uncovered

Limb or organ regrowth may be hidden in our genes

"If you trace our evolutionary tree way back to its roots -- long before the shedding of gills or the development of opposable thumbs -- you will likely find a common ancestor with the amazing ability to regenerate lost body parts."

"Lucky descendants of this creature, including today's salamanders or zebrafish, can still perform the feat, but humans lost much of their regenerative power over millions of years of evolution."   (hmmmm)
"We want to find more of these types of elements so we can understand what turns on and ultimately controls the program of regeneration," said Poss (programs are designed)

A prior post here by John Sanford and genetic entropy - "the human race is degenerating at 1-5% per generation"

"so it's kind of a trade secret amongst population geneticists,any well informed population geneticist understands man is degenerating"

"so in deep geological time we should have been extinct a long time ago"

Tuesday, March 22, 2016

Exoplanet Census Suggests Earth Is Special after All

The latest from Scientific American.  Is the Copernican Principle being overturned?  Stay tuned....

Exoplanet Census Suggests Earth Is Special after All

A new tally proposes that roughly 700 quintillion terrestrial exoplanets are likely to exist across the observable universe—most vastly different from Earth

"But the average age of these planets—well above Earth’s age—and their typical locations—in galaxies vastly unlike the Milky Way—just might turn the Copernican principle on its head.

"But Max Tegmark from the Massachusetts Institute of Technology, who also was not part of the research, thinks Earth is a colossal violation of the Copernican principle..."


Planck Satellite Confirms WMAP Findings: Universe is not Copernican

The Modern World is Faced with the Breach of a Far Reaching Paradigm

 "The question is ‘what will modern science do now’? Will they invent additional parameters to keep the current theories alive (in addition to those already added: dark matter, dark energy, redshift as expansion, big bang inflation, etc.) or will they consider the possibility that we are in a special place as observations clearly indicate?"


Do We Live in a Giant Cosmic Bubble? 

"This idea that we live in a void would really be a statement that we live in a special place," Clifton told "The regular cosmological model is based on the idea that where we live is a typical place in the universe. This would be a contradiction to the Copernican principle."
"This idea that we live in a void would really be a statement that we live in a special place," Clifton told "The regular cosmological model is based on the idea that where we live is a typical place in the universe. This would be a contradiction to the Copernican principle."

Saturday, February 13, 2016

Biology of the Baroque

Can Darwinism explain beauty in nature?  God is an artist of such beauty.  IDvolution - God “breathed” the super language of DNA into the “kinds” in the creative act reflecting His beauty.

"The Biology of the Baroque" is a documentary that explores the amazing patterns, order, and beauty in biology that go beyond what can be explained by Darwinian evolution. It features geneticist Michael Denton and is inspired by Denton's new book Evolution: Still a Theory in Crisis"