Study reveals the inner workings of a molecular motor that packs and unpacks DNA

Precision, complexity, organization, heavy duty, astounding , react rapidly to alterations in their environment - all through BUC.

The more we learn the harder it is for evo proponents to advocate with a straight face. It looks designed but we know it isn’t. 

Study reveals the inner workings of a molecular motor that packs and unpacks DNA

Moreover, the entire DNA must be replicated before cell division and DNA damage needs to be repaired.

This is when chromatin remodelers come into play. Chromatin remodelers have an essential role as they are molecular machines: they unpick and unpack segments of the DNA by sliding nucleosome spools back and forth, replacing individual histones, freeing up the DNA for transcription, and finally compacting it again, when the job is done. Since all of this happens in a highly dynamic fashion, chromatin remodelers enable cells to react rapidly to alterations in their environment – and this holds for brewer’s yeast as well as for human cells. In mediating gene accessibility, chromatin remodelers are vital for development and cell differentiation; cell types are defined by the sets of genes they express, remodelers help to determine cell identity.

From a biochemical point of view, remodelers are responsible for heavy-duty reorganizational tasks. To perform these tasks, they must execute “large-scale conformational changes, which are carried out with astounding precision,”

 phys.org

Study reveals the inner workings of a molecular motor that packs and unpacks DNA

The clouds of spaghetti that keep DNA data safe

The clouds of spaghetti that keep DNA data safe

Cells can avoid “data breaches” when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert Einstein College of Medicine have shown. Their study appears in the March 23 issue of the Journal of Biological Chemistry.

In every human cell, all of the body’s blueprints and instructions are stored in the form of DNA inside the nucleus. Molecules that need to travel in and out of the nucleus – to turn genes on or off or retrieve information – do so through passageways called nuclear pore complexes (NPCs). Traffic through these NPCs must be tightly controlled in order to prevent DNA hijacking by viruses or faulty functioning as in cancer.

"How on Earth do you have the kind of specificity that we see in protein-protein interactions like antibodies, and yet have the kind of speed that we see with water off a Teflon pan?"

"I can’t think of any analogy in normal life that does what this does," Rout said. "You’ve got this blur of (amino acids) coming on and off (the transport factor) with extraordinary speed."

ScienceDaily

Royal Society Meeting - Modern Synthesis is Broken

Read a report on the Royal Society Meeting

“The Modern Synthesis, while undoubtedly productive for a time, is a misconception of reality that has reached the limits of its explanatory power. The problems are fundamental. No amount of cosmetic surgery is going correct them.”

“To the contrary, Darwinian competition causes not the evolution of species but the destruction of species.It is collaboration in its various forms that causes biological evolution. Hence I’m surprised by calls for extending the neo-Darwinian Evolutionary Synthesis. You can’t extend something that is broken. Surely what is needed now, after 65 years, is using the empirical evidence to develop a new paradigm for biological evolution.”

"If you want the definition of the Modern Synthesis, take a look at how Neil deGrasse Tyson explains evolution in the 2014 remake of Carl Sagan’s Cosmos series. Tyson, an astrophysicist, is unaware that he is misinformed, as are most in science, academia, government, literature, the arts, and the public by this outmoded theory of evolution."

“Shuker tried to interrupt but Noble held his ground:
‘No, YOU need to listen. I used to think exactly like you. I embraced the reductionist mindset for years. When I got out of school I was a card-carrying reductionist. Reductionism is powerful and it’s useful. I am not dissing it. Many times we need it. But it is not the whole story.’ Noble described how bacterial regulatory
networks rebuilt those genes in four days by hyper-mutating, actively searching for a solution that would give them tails and enable them to Nind food. Natural selection did not achieve that. Natural genetic engineering did.’”

“It’s appropriate that this meeting is being held at the Royal Society, whose motto, we were reminded yesterday, is “Nullius in verba”: Accept nothing on authority."

“Not one whit of empirical evidence shows that new species arise from the neo-Darwinian mechanism. To the contrary, Darwinian competition causes not the evolution of species but the destruction of species.”

http://www.envevo.org/environmentalevolution.org/Home_files/Jan2017envevo_newsletter.pdf

Fine tuning of Light, to Atmosphere, Water, Photosynthesis, and Human Vision

Fine tuning of Light, to Atmosphere, Water, Photosynthesis, and Human Vision

Human and chimp Y chromosomes are very different - Horrendously Different

Human and chimp Y chromosomes are very different - Horrendously Different

ATP Synthase: The power plant of the cell

ATP Synthase: The power plant of the cell - has a rotor, stator, driveshaft and camshaft.  The amazing design of life on display in this animation.  Another chicken and egg question:  What came first the motor or the energy?

Sophistication, coordination and communication of cells

Each day we learn more that supports the complexity of life.  Cells communicating, cooperating, working in concert, aware of each other all by chance.  Not a chance.  It smacks of design and programming. 

How cells communicate to move together as a group

Two cell membrane proteins, Fat2 and Lar, trigger leading and trailing edge movements during epithelial migration

A new signaling system has been discovered that epithelial cells use to coordinate their individual movements and efficiently move tissues, report scientists.  

"When an individual cell needs to move somewhere, it manages just fine on its own. It extends protrusions from its leading edge and retracts the trailing edge to scoot itself along, without having to worry about what the other cells around it are doing. But when cells are joined together in a sheet of tissue, or epithelium, they have to coordinate their movements with their neighbors. It's like walking by yourself versus navigating a crowded room. To push through the crowd, you have to communicate with others by talking ("Pardon me") or tapping them on the shoulder. Cells do the same thing, but instead of verbal cues and hand gestures, they use proteins to signal to each other."